Cortisone shots are injections that can help relieve pain and inflammation in a specific area of your body. They're most commonly injected into joints — such as your ankle, elbow, hip, knee, shoulder, spine or wrist. Even the small joints in your hands or feet might benefit from cortisone shots. The injections usually contain a corticosteroid medication and a local anesthetic. Because of potential side effects, the number of shots you can get in a year is limited.